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Use of two unrelated umbilical cord stem cell units in stem cell transplantation for Wiskott-Aldrich syndrome

Lookup NU author(s): Professor Mary Slatter, Dr Baidik Bhattacharya, Dr Terence Flood, Dr Mario Abinun, Professor Andrew Cant, Professor Andrew GenneryORCiD

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Abstract

Wiskott-Aldrich syndrome, an X-linked primary immunodeficiency can be cured by bone marrow transplantation. Umbilical cord haemopoietic stem cells are increasingly used as an alternative to bone marrow; advantages include ready availability, no risk to the donor, low rate of viral contamination, and low risk of graft versus host disease. Disadvantages include low stem cell dose for larger patients and lack of stem cells for boost infusions following the initial procedure. We report the case of a child with Wiskott-Aldrich syndrome who underwent cord blood stem cell transplantation with two separate cord blood units, 8 days apart. © 2005 Wiley-Liss, Inc.

Publication metadata

Author(s): Slatter MA, Bhattacharya A, Flood TJ, Abinun M, Cant AJ, Gennery AR

Publication type: Article

Publication status: Published

Journal: Pediatric Blood and Cancer

Year: 2006

Volume: 47

Issue: 3

Pages: 332-334

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/pbc.20450

DOI: 10.1002/pbc.20450

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