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Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice

Lookup NU author(s): Dr Lisa Ferguson, Professor Mary Herbert

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Abstract

The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes (univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes. © 2007 Nature Publishing Group.

Publication metadata

Author(s): Kouznetsova A, Lister L, Nordenskjold M, Herbert M, Hoog C

Publication type: Article

Publication status: Published

Journal: Nature Genetics

Year: 2007

Volume: 39

Issue: 8

Pages: 966-968

Print publication date: 01/08/2007

ISSN (print): 1061-4036

ISSN (electronic): 1546-1718

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ng2065

DOI: 10.1038/ng2065

PubMed id: 17618286

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