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Lookup NU author(s): Dr Michael Carroll, Reice Wood
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Extensive studies on the reaction of the fluoride ion with diaryliodonium salts demonstrated that this is a generic process for the formation of fluoroarenes and has particular advantages for the preparation of fluorine-18 radiopharmaceuticals. During these studies it became apparent that nucleophiles other than the fluoride ion may be employed for generating substituted aromatics. This approach can be applied, using substituted anilines as the nucleophilic reagent, to the formation of a range of diarylamines in good yield. Optimised conditions for the reaction of a diaryliodonium salt with an aniline utilise TFA as the preferred counter-ion in DMF (130 °C, 24 h). © 2007 Elsevier Ltd. All rights reserved.
Author(s): Carroll MA, Wood RA
Publication type: Article
Publication status: Published
Journal: Tetrahedron
Year: 2007
Volume: 63
Issue: 46
Pages: 11349-11354
ISSN (print): 0040-4020
ISSN (electronic): 1464-5416
Publisher: Pergamon
URL: http://dx.doi.org/10.1016/j.tet.2007.08.076
DOI: 10.1016/j.tet.2007.08.076
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