Toggle Main Menu Toggle Search

Open Access padlockePrints

The impact of transurethral resection of bladder tumour on serum levels of soluble E-cadherin

Lookup NU author(s): Garrett Durkan, Dr Ian Brotherick, Kilian Mellon

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Objective To evaluate soluble E-cadherin (sE-cadherin) as a potential tumour marker in patients with transitional cell carcinoma (TCC) of the bladder (previously shown to correlate with tumour grade, number of Ta/T1 tumours at presentation and a positive 3-month check cystoscopy) by assessing its serum concentration in relation to transurethral resection of bladder tumour (TURBT). Patients and methods Samples of venous blood were obtained from 25 patients with bladder cancer: ii) before cystoscopy/TURBT: iii intraoperatively, during tumour resection: and (iii! on the first day after surgery. Levels of sE-cadherin were measured using an enzyme-linked immunosorbent assay. Results Sixty-three serum samples from patients with TCC of the bladder were available for analysis (23 before, 21 during and 19 after surgery). Patients with G2/3 tumours had significantly higher median preoperative levels of sE-cadherin (16.37 and 13.03 mu g/mL, respectively) than those with G1 tumours (9.493 mu g/mL; P= 0.0164). There was no correlation between tumour stage and preoperative sE-cadherin concentration. The median concentrations of sE-cadherin were not significantly different before, during and after TURBT. Conclusions This study confirmed the previous finding that higher levels of serum sE-cadherin correlate with increasing tumour grade but not with clinicopathological stage. Serum sE-cadherin levels are not significantly altered by TURBT in the immediate perioperative period.


Publication metadata

Author(s): Durkan GC, Brotherick I, Mellon JK

Publication type: Article

Publication status: Published

Journal: BJU International

Year: 1999

Volume: 83

Issue: 4

Pages: 424-428

ISSN (print): 1464-4096

ISSN (electronic): 1464-410X

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1046/j.1464-410x.1999.00972.x

DOI: 10.1046/j.1464-410x.1999.00972.x


Altmetrics

Altmetrics provided by Altmetric


Share