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Self-reported adherence to treatment with mood stabilizers, plasma levels, and psychiatric hospitalization

Lookup NU author(s): Jean Scott, Marie Pope

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Abstract

Objective: The authors explored the relationship of adherence to treatment with mood stabilizers (lithium, carbamazepine, and sodium valproate) and plasma levels of these drugs to future psychiatric hospitalizations. Method: They prospectively followed 98 patients with mood disorders who were prescribed mood stabilizers. These patients participated in an initial interview and completed a questionnaire regarding their adherence to the medications. Data on their plasma levels of these drugs were taken from assays done in the 3 months before the interview. Results: Six of the 98 patients were not classified as to medication adherence or plasma levels. Twenty-nine (32%) of the remaining patients reported partial adherence to the medication regimen, and 33 (36%) had an index plasma level that was suboptimal. At 18 months, rates of admission to a psychiatric hospital were significantly higher in the 16 partially adherent patients with subtherapeutic plasma levels (N=13, 81%) than in the 46 adherent patients with therapeutic plasma levels (N=4, 9%). However, hospital admission was also more likely in partially adherent patients with therapeutic plasma levels than in adherent patients with subtherapeutic plasma levels. Conclusions: Adherence to medication regimens may be a proxy measure of other healthy behaviors.


Publication metadata

Author(s): Scott J, Pope M

Publication type: Article

Publication status: Published

Journal: American Journal of Psychiatry

Year: 2002

Volume: 159

Issue: 11

Pages: 1927-1929

ISSN (print): 0002-953X

ISSN (electronic): 1535-7228

Publisher: American Psychiatric Publishing, Inc.

URL: http://dx.doi.org/10.1176/appi.ajp.159.11.1927

DOI: 10.1176/appi.ajp.159.11.1927


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