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Phenotype and frequency of Epstein-Barr virus-infected cells in pretreatment blood samples from patients with Hodgkin lymphoma

Lookup NU author(s): Dr Amelia Lake, Dr Penelope Taylor

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Abstract

An accumulating body of data suggests that the Epstein-Barr virus (EBV), a lymphotropic herpesvirus, is involved in the pathogenesis of a proportion of cases of Hodgkin lymphoma (HL). In this study, we showed that the frequency of circulating EBV-infected cells was significantly higher (P < 0.001) in pretreatment blood samples from EBV-associated cases when compared with non-EBV-associated cases. We further showed that in patients with EBV-associated disease, the virus persisted in the peripheral blood in memory B cells. This phenotype is consistent with that seen in healthy seropositive controls, post-transplant patients and patients with acute infectious mononucleosis. The data suggest that an increased frequency of EBV carrying B cells in peripheral blood is associated with EBV-associated HL.

Publication metadata

Author(s): Khan G, Lake A, Shield L, Freeland J, Andrew L, Alexander FE, Jackson R, Taylor PRA, McCruden EAB, Jarrett RF

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2005

Volume: 129

Issue: 4

Pages: 511-519

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2141.2005.05483.x

DOI: 10.1111/j.1365-2141.2005.05483.x

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