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SPECT imaging of the alpha 4 beta 2 nicotinic receptor using (5-I-123)A85380

Lookup NU author(s): Dr Margaret Piggott

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Abstract

In order to image nAChR density in vivo in humans, [5- I-123] -iodo-3-[2(S)-2-azetidinylmethoxylpyridine ([5- I-123]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, in vitro validation in human post-mortem tissue and some initial in vivo clinical studies using the ligand [5-I-123/125]A85380. Limitations of the usefulness of the tracer for routine clinical use are also discussed. Copyright (c) 2007 John Wiley & Sons, Ltd.


Publication metadata

Author(s): Pimlorr SL, Piggott M, Patterson J, Cavanagh J, Wyper DJ

Publication type: Article

Publication status: Published

Journal: Journal of Labelled Compounds and Radiopharmaceuticals

Year: 2007

Volume: 50

Issue: 5-6

Pages: 350-353

ISSN (print): 0362-4803

ISSN (electronic): 1099-1344

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1002/jlcr.1192

DOI: 10.1002/jlcr.1192


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