Lookup NU author(s): Dr Caroline Matthews,
Dr Chris Redfern,
Professor Barry Hirst
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Electrogenic ion transport across human endometrial epithelial cells grown as polarized monolayers on permeable supports was measured as an inward short-circuit current (I(SC); 16.2+/-1.1 muA/cm2). Bombesin (10(-7) m) and human gastrin-releasing peptide (GRP; 10(-7) M) caused transient enhancement of this I(SC). These effects were largely restricted to the basolateral surface of the cells; responses to apical peptide were modest in comparison with those to basolateral peptide. GRP and other bombesin-related peptides may have a role in regulation of endometrial epithelial ion transport in vivo and thereby influence the intra-uterine environment.
Author(s): Matthews CJ, Redfern CPF, Thomas EJ, Hirst BH
Publication type: Article
Publication status: Published
Journal: Experimental Physiology
Print publication date: 01/09/1993