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Bombesin and gastrin-releasing peptide stimulate electrogenic ion transport in cultured human endometrial epithelial cell layers

Lookup NU author(s): Dr Caroline Matthews, Dr Chris Redfern, Professor Barry Hirst

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Abstract

Electrogenic ion transport across human endometrial epithelial cells grown as polarized monolayers on permeable supports was measured as an inward short-circuit current (I(SC); 16.2+/-1.1 muA/cm2). Bombesin (10(-7) m) and human gastrin-releasing peptide (GRP; 10(-7) M) caused transient enhancement of this I(SC). These effects were largely restricted to the basolateral surface of the cells; responses to apical peptide were modest in comparison with those to basolateral peptide. GRP and other bombesin-related peptides may have a role in regulation of endometrial epithelial ion transport in vivo and thereby influence the intra-uterine environment.


Publication metadata

Author(s): Matthews CJ, Redfern CPF, Thomas EJ, Hirst BH

Publication type: Article

Publication status: Published

Journal: Experimental Physiology

Year: 1993

Volume: 78

Issue: 5

Pages: 715-718

Print publication date: 01/09/1993

ISSN (print):

ISSN (electronic):


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