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Retinoic acid receptor expression during the in vitro differentiation of human neuroblastoma

Lookup NU author(s): Professor Penny Lovat, Professor Andrew Pearson, Professor Archibald Malcolm, Dr Chris Redfern

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Abstract

Neuroblastoma cells differentiate in response to retinoic acid and cyclic AMP. We have examined the expression of retinoic acid receptors (RARs) in relation to neuroblastoma differentiation and show that short term exposure of SK N SH, SH SY 5Y AND GI LI N cells to physiological concentrations of retinoic acid results in induction of RAR-beta, particularly the lower transcript. Cyclic AMP has no effect on retinoic acid mediated induction and does not alter RAR expression patterns. These data are discussed in the light of evidence that retinoic acid and cyclic AMP act either on different control pathways or at different points within a common pathway.


Publication metadata

Author(s): Lovat PE, Pearson ADJ, Malcolm AJ, Redfern CPF

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 1993

Volume: 162

Issue: 1-2

Pages: 109-113

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/0304-3940(93)90572-3

DOI: 10.1016/0304-3940(93)90572-3

PubMed id: 8121610


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