Lookup NU author(s): Professor Penny Lovat,
Professor Andrew Pearson,
Professor Archibald Malcolm,
Dr Chris Redfern
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Neuroblastoma cells differentiate in response to retinoic acid and cyclic AMP. We have examined the expression of retinoic acid receptors (RARs) in relation to neuroblastoma differentiation and show that short term exposure of SK N SH, SH SY 5Y AND GI LI N cells to physiological concentrations of retinoic acid results in induction of RAR-beta, particularly the lower transcript. Cyclic AMP has no effect on retinoic acid mediated induction and does not alter RAR expression patterns. These data are discussed in the light of evidence that retinoic acid and cyclic AMP act either on different control pathways or at different points within a common pathway.
Author(s): Lovat PE, Pearson ADJ, Malcolm AJ, Redfern CPF
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
Publisher: Elsevier Ireland Ltd
PubMed id: 8121610
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