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Operational criteria for senile dementia of Lewy body type (SDLT)

Lookup NU author(s): Professor Ian McKeith, Emeritus Professor Robert Perry, Dr Andrew Fairbairn, Emeritus Professor Elaine Perry

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Abstract

Recent reports have suggested that brain stem and cortical Lewy body formation may identify a neurodegenerative disorder in elderly demented individuals which accounts for up to 20 % of cases of senile dementia coming to autopsy. Retrospective analysis of case notes of 21 autopsy patients with neuropathologically proven senile dementia of Lewy body type (SDLT) and 37 cases with neuropathologically proven Alzheimer's disease (AD) identified a characteristic clinical syndrome in SDLT. Fluctuating cognitive impairment; psychotic features including visual and auditory hallucinations, and paranoid delusions; depressive symptoms; falling and unexplained losses of consciousness were all seen significantly more often than in AD. Over half of the SDLT patients in this series who were given neuroleptics in standard dose showed acute and often irreversible adverse reactions indicative of a neuroleptic sensitivity syndrome. The survival time of drug treated patients was reduced by 50 %. Operational criteria to aid in the clinical distinction between SDLT and AD patients are proposed and hypotheses regarding possible aetiology and treatment discussed.


Publication metadata

Author(s): McKeith IG, Perry RH, Fairbairn AF, Jabeen S, Perry EK

Publication type: Article

Publication status: Published

Journal: Psychological Medicine

Year: 1992

Volume: 22

Issue: 4

Pages: 911-922

Print publication date: 01/11/1992

ISSN (print): 0033-2917

ISSN (electronic): 1469-8978

Publisher: Cambridge University Press

URL: http://dx.doi.org/10.1017/S0033291700038484

DOI: 10.1017/S0033291700038484


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