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Cytogenetic abnormalities in a disseminated medulloblastoma

Lookup NU author(s): Professor Andrew Pearson, John Emslie, Dr Anne Lennard, Emeritus Professor Robert Perry, Peter Crawford

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Abstract

A 3-year-old girl developed central nervous system, bone and bone marrow metastases, and hypercalcaemia shortly after presentation with medulloblastoma. Cytogenetic studies of the involved bone marrow showed multiple abnormalities including iso(17q). This chromosome rearrangement has been reported in other cases of recurrent or disseminated medulloblastoma. More studies are required relating the karyotypes of medulloblastomas to long-term outcome to determine if the presence of iso(17q) is a prognostic factor in this malignancy.


Publication metadata

Author(s): Stuart AG, Pearson ADJ, Emslie J, Lennard AL, Davison EV, Perry RH, Crawford PJ

Publication type: Article

Publication status: Unknown

Journal: Medical and Pediatric Oncology

Year: 1993

Volume: 21

Issue: 4

Pages: 295-298

Print publication date: 01/01/1993

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017


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