Lookup NU author(s): Professor Penny Lovat,
Professor Andrew Pearson,
Professor Archibald Malcolm,
Dr Chris Redfern
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The observation that neuroblastoma cells differentiate in response to retinoic acid (RA) in vitro has led to clinical trials using either 13-cis or all-trans RA. Since 9-cis RA may also have important biological functions, we have compared the potential of RA isomers to induce differentiation and inhibit cell proliferation of SH SY 5Y neuroblastoma cells. 9-cis RA at high concentrations is better at inducing morphological differentiation than either all-trans or 13-cis RA and as effective at inhibiting proliferation. Hence, 9-cis RA or stable analogues may have important therapeutic potential in the treatment of neuroblastoma.
Author(s): Lovat PE, Lowis SP, Pearson ADJ, Malcolm AJ, Redfern CPF
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
Print publication date: 01/11/1994
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
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