Toggle Main Menu Toggle Search

ePrints

Concentration-dependent effects of 9-cis retinoic acid on neuroblastoma differentiation and proliferation in vitro

Lookup NU author(s): Professor Penny Lovat, Professor Andrew Pearson, Professor Archibald Malcolm, Dr Chris Redfern

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

The observation that neuroblastoma cells differentiate in response to retinoic acid (RA) in vitro has led to clinical trials using either 13-cis or all-trans RA. Since 9-cis RA may also have important biological functions, we have compared the potential of RA isomers to induce differentiation and inhibit cell proliferation of SH SY 5Y neuroblastoma cells. 9-cis RA at high concentrations is better at inducing morphological differentiation than either all-trans or 13-cis RA and as effective at inhibiting proliferation. Hence, 9-cis RA or stable analogues may have important therapeutic potential in the treatment of neuroblastoma.


Publication metadata

Author(s): Lovat PE, Lowis SP, Pearson ADJ, Malcolm AJ, Redfern CPF

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 1994

Volume: 182

Issue: 1

Pages: 29-32

Print publication date: 01/11/1994

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

URL: http://dx.doi.org/10.1016/0304-3940(94)90197-X

DOI: 10.1016/0304-3940(94)90197-X


Altmetrics

Altmetrics provided by Altmetric


Actions

    Link to this publication


Share