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The mRNA-binding protein COLBP is glutamate dehydrogenase

Lookup NU author(s): Professor Zofia Chrzanowska-Lightowlers, Professor Robert Lightowlers

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Abstract

Expression of the liver-type isopeptides of cytochrome c oxidase is regulated post-transcriptionally. An RNA-binding activity has been found in only those cells where the liver-type subunits are detected, This binding protein, termed COLBP, recognises sequences or structures within the 3'-untranslated regions of transcripts encoding these liver-type isopeptides and has been implicated in the modulation of mRNA expression, We now show by subcellular fractionation, immunocompetition, UV-crosslinking and shift-Western studies that the metabolic enzyme glutamate dehydrogenase, previously reported as being able to bind RNA, is the cytochrome c oxidase transcript-binding protein, COLBP.


Publication metadata

Author(s): Preiss T, Sang AE, Chrzanowska-Lightowlers ZMA, Lightowlers RN

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 1995

Volume: 367

Issue: 3

Pages: 291-296

Print publication date: 01/07/1995

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/0014-5793(95)00569-U

DOI: 10.1016/0014-5793(95)00569-U


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