Lookup NU author(s): Professor Zofia Chrzanowska-Lightowlers,
Professor Robert Lightowlers,
Professor Doug Turnbull
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Defects of the mitochondrial genome are increasingly being recognised as important causes of disease. Patients may present at any age and the symptoms vary from fatal lactic acidosis in infancy to muscle disease in adults. For most patients there is no satisfactory treatment and there is a gradual deterioration leading to severe disability and death. In the absence of any biochemical treatment, gene therapy must be considered for these patients. This review addresses the unique problems associated with the treatment of defects of the mitochondrial genome by gene therapy, and discusses the approaches which we believe may be of value.
Author(s): Chrzanowska-Lightowlers ZMA, Lightowlers RN, Turnbull DM
Publication type: Review
Publication status: Published
Journal: Gene Therapy
Print publication date: 01/07/1995
ISSN (print): 0969-7128
ISSN (electronic): 1476-5462