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Lookup NU author(s): Dr Linda Hogarth, Professor Andrew Pearson, Dr Andrew Hall
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Glutathione (GSH) has been implicated as an important factor in the detoxification of many electrophilic xenobiotics, including agents used in cytotoxic chemotherapy. Maintenance of high levels of GSH in normal tissues is believed to be important in the prevention of drug-induced toxicity. Previous studies have indicated that exposure of cells to some toxic electrophiles both in vitro and in vivo can cause a temporary decrease in intracellular levels of GSH. In this paper we report that in a series of 22 children and young adults treated with high dose melphalan (ten courses studied, all 200 mg/m(2)), cisplatin (eight courses, 80-104 mg/m(2)) or carboplatin (seven courses, 507-750 mg/m(2)) there was no significant alteration in the level of plasma, erythrocyte or urine GSH in the period immediately following drug administration. Fluctuations in the level of GSH in mononuclear cells were observed in some patients but did not follow any consistent pattern and were similar to those observed in a series of nine normal adult controls over the same time course. These results suggest that for melphalan, cisplatin and carboplatin, drug-GSH adduct formation is insufficient to cause a measurable decrease in intracellular GSH levels in normal peripheral haematopoietic cells during the course of treatment.
Author(s): Hogarth LA, English M, Price L, Wyllie R, Pearson ADJ, Hall AG
Publication type: Article
Publication status: Published
Journal: Cancer Chemotherapy and Pharmacology
Year: 1996
Volume: 37
Issue: 5
Pages: 479-485
Print publication date: 08/02/1996
ISSN (print): 0344-5704
ISSN (electronic): 1432-0843
URL: http://dx.doi.org/10.1007/s002800050415
DOI: 10.1007/s002800050415
PubMed id: 8599872
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