Lookup NU author(s): Professor Jim Edwardson,
Emeritus Professor Robert Perry,
Professor Ian McKeith,
Dr Christopher Morris
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
HLA-DR antigen types were determined from DNA isolated from post-mortem brain tissue of age-matched groups of 78 patients with pathologically confirmed late-onset Alzheimer's disease (AD) and 50 controls. The results suggest that for individuals with no apolipoprotein E epsilon 4 alleles the presence of either DR1, 2 or 3 antigens is associated with a significantly increased risk for development of late-onset AD. Conversely the DR4 or 6 antigens are associated with a decreased risk of similar magnitude. This DR effect, rather than prolonged use of non-steroidal anti-inflammatory drugs, could be responsible for the reported lower prevalence of AD in rheumatoid arthritis (a condition associated with an increased frequency of DR-4).
Author(s): McKeith I; Edwardson J; Perry R; Morris C; Neill D; Curran M; Middleton D
Publication type: Article
Publication status: Published
Print publication date: 01/04/1997
ISSN (print): 0959-4965
ISSN (electronic): 1473-558X
Publisher: Lippincott Williams & Wilkins
Altmetrics provided by Altmetric