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Apoptosis in neuroblastomas induced by interferon-gamma involves the CD95/CD95L pathway

Lookup NU author(s): Professor Penny Lovat, Dr Chris Redfern, Professor Andrew Pearson

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Abstract

Background and Procedure. The CD95/ CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated the constitutive and interferon gamma (INF gamma)-induced expression of CD95 and CD95L, and CD95-mediated cell death in the SK-N-BE(2) cell line. Results. Modulation of CD95/CD95L expression and triggering of an autocrine apoptotic mechanism by IFN gamma suggest a potential role for INF gamma as a therapeutic agent for NE. Conclusions. The evidence that retinoids induce apoptosis via tissue transglutaminase (tTC) and that N-methyl-D-aspartate (NMDA) and gp120 act through the nitric oxide synthase (NOS) activation pathway, indicates the existence of different molecular mechanisms of action, whose pharmacological exploitation might be used in an additive fashion. Med. Pediatr. Oncol. 36:115-117, 2001. (C) 2001 Wiley-Liss, inc.


Publication metadata

Author(s): Annicchiarico-Petruzzelli, M., Bernassola, F., Lovat, P.E., Redfern, C.P.F., Pearson, A.D.J., Melino, G.

Publication type: Article

Publication status: Unknown

Journal: Medical and Pediatric Oncology

Year: 2001

Volume: 36

Issue: 1

Pages: 115-117

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

URL: http://dx.doi.org/10.1002/1096-911X(20010101)36:1<115::AID-MPO1027>3.0.CO;2-X

DOI: 10.1002/1096-911X(20010101)36:1<115::AID-MPO1027>3.0.CO;2-X


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