ePrints

Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids

Lookup NU author(s): Dr Ian HardcastleORCiD, Meg Barber

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

The efficient synthesis of a small library of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids is described via the fluoride mediated alkylation of 5,6,8-trifluoro-7-hydroxy-2-methyl-benzo[1,3]dioxin-4-one with a collection of structurally diverse bromoalkanes. The use of ion-exchange resins during the reaction sequence enabled the preparation of the majority of the products in 82-98% purity without the need for chromatography. (C) 2001 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Hardcastle IR, Barber AM, Marriott JH, Jarman M

Publication type: Article

Publication status: Published

Journal: Tetrahedron Letters

Year: 2001

Volume: 42

Issue: 7

Pages: 1363-1365

ISSN (print): 0040-4039

ISSN (electronic): 1873-3581

URL: http://dx.doi.org/10.1016/S0040-4039(00)02252-8

DOI: 10.1016/S0040-4039(00)02252-8

Altmetrics

Share