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Relation between heart rate and pulse transit time during paced respiration

Lookup NU author(s): Dr Michael Drinnan, Dr John Allen, Professor Alan Murray

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Abstract

Pulse transit time (PTT) is a simple, non-invasive measurement, defined as the time taken from a reference time for the pulse pressure wave to travel to the periphery. PTT is influenced by heart rate, blood pressure changes and the compliance of the arteries, but few quantitative data are available describing the factors which influence PTT. The aim of this study was to investigate the relationship between the cardiac beat-to-beat interval (RR) and PTT, using paced respiration to generate changes in both variables. We analysed PTT and RR interval from 15 normal healthy subjects during paced breathing, and the cross-correlation function between PTT and RR was used to quantify their relationship. Over the 15 subjects, the maximum change in PTT ranged from 7 to 23 ms with a mean +/- standard deviation of 14 +/- 5 ms, and that in RR interval from 86 to 443 ms (241 +/- 102 ms). Examining changes over time, the best correlation (r = +0.69, p < 0.01) was obtained when PTT was advanced relative to RR, with a change in RR followed by a corresponding change in PTT 3.17 0.76 beats later. We conclude that there is a strong relationship between PTT changes and RR interval changes, but these changes are not in phase.


Publication metadata

Author(s): Murray A; Drinnan MJ; Allen J

Publication type: Article

Publication status: Published

Journal: Physiological Measurement

Year: 2001

Volume: 22

Issue: 3

Pages: 425-432

ISSN (print): 0967-3334

ISSN (electronic): 1361-6579

Publisher: Institute of Physics Publishing Ltd.

URL: http://dx.doi.org/10.1088/0967-3334/22/3/301

DOI: 10.1088/0967-3334/22/3/301


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