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Lookup NU author(s): Professor Ian McKeith, Dr Evelyn Jaros, Dr Andrew Fairbairn, Dr Clive Ballard, Dr Janet Grace, Dr Christopher Morris, Emeritus Professor Robert Perry
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Several hospital based autopsy series indicate dementia with Lewy bodies (DLB) to be the second most common pathological subtype of degenerative dementia in elderly subjects. The majority of DLB cases have high densities of beta amyloid senile plaques, whereas neocortical neurofibrillary tangle density is only slightly increased above age-matched normal control values and over tenfold lower than the average in Alzheimer's disease. The interpretation of this Alzheimer type pathology is problematic. reflecting in part changing views about the neuropathological diagnosis of AD itself. AD is characterised by hyperphosphorylation of the microtubular associated protein tau, and DLB by neurofilament abnormalities including phosphorylation, ubiquitination, proteolysis, and cross-linking of constituent proteins. The two diseases appear therefore to be distinct at an ultrastructural and molecular level, a conclusion which is consistent with the fact that the clinical syndromes associated with DLB and AD are sufficiently differentiated to allow for accurate antemortem diagnosis.
Author(s): McKeith IG; Fairbairn A; Perry RH; Grace J; Morris CM; Ballard C; Jaros EB; Ince P
Publication type: Article
Publication status: Published
Journal: Journal of Neural Transmission Supplement
Year: 1998
Issue: 54
Pages: 107-116
Print publication date: 01/01/1998
ISSN (print): 0303-6995
ISSN (electronic):
Publisher: Springer Wien
