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Nicotinic receptors in the putamen of patients with dementia with Lewy bodies and Parkinson's disease: relation to changes in alpha-synuclein expression

Lookup NU author(s): Dr Carmen Martin-Ruiz, Dr Margaret Piggott, Dr Mark Cookson, Emeritus Professor Robert Perry, Dr Evelyn Jaros, Emeritus Professor Elaine Perry, Dr Jennifer Court

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Abstract

A reduction in nicotinic receptor (nAChR) binding has previously been observed in putamen in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The present study demonstrates no concommitant reduction in the expression of alpha2-alpha7, beta2 and beta3 nAChR subunit proteins. Alphasynuclein, which can interfere with membrane protein function and is a key constituent of PD and DLB pathology, was increased (insoluble fraction) in both disorders, although nAChR binding loss did not correlate with a-synuclein expression within patient groups. The results point to a possible abnormality of striatal nicotinic receptor assembly in PD and DLB. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Piggott M; Perry RH; Cookson MR; Perry EK; Court JA; Martin-Ruiz C; Lawrence S; Kuryatov A; Lindstrom J; Gotti C; Jaros E

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2002

Volume: 335

Issue: 2

Pages: 134-138

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/S0304-3940(02)01183-7

DOI: 10.1016/S0304-3940(02)01183-7


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