Toggle Main Menu Toggle Search

Open Access padlockePrints

Carcinoma ex benign pleomorphic adenoma of the parotid gland

Lookup NU author(s): Dr Charles Kelly, Neil McLean

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Background: Carcinoma in pleomorphic salivary adenoma is a common histologic subtype of primary parotid malignancy. Methods: In this study, 28 patients (predominantly male) with histologically diagnosed carcinoma in pleomorphic salivary adenoma presenting over 10 years were retrospectively reviewed. Results: Only 25 percent of patients had a previously treated pleomorphic salivary adenoma. Although the presenting features suggested malignancy in some cases, overall they were nonspecific, overlapping with the presentation of benign disease. Preoperative investigations included fine needle aspiration cytology, which was only 29-percent sensitive, and computed tomography and/or magnetic resonance imaging. There were 14 superficial and 12 total or radical parotidectomies. The facial nerve was resected en bloc with the tumor in nine cases and immediately reconstructed with good reanimation results in patients with recent-onset facial paresis. Only 44 percent of patients had a complete histologic tumor clearance, and this was the most significant determinant of survival (p < 0.01, log-rank analysis). The locoregional control rate was 66 percent at 5 years, but recurrent disease proved invariably fatal. Five-year disease-specific survival was 44 percent With a high rate of disease-specific mortality (87 percent). Conclusions: Carcinoma in pleomorphic salivary adenoma is very difficult to diagnose preoperatively. Fine needle aspiration cytology had a disappointingly low sensitivity for this tumor, potentially misdirecting surgical management. While good locoregional disease control could be achieved With surgery and radiotherapy, carcinoma in pleomorphic salivary adenoma was shown to be aggressive with a high disease-specific rate of mortality. Given that incomplete tumor resection was the most important prognostic factor, a high index of clinical suspicion, radical ablative surgery, and immediate soft-tissue and nerve reconstruction for proven cases are advocated.


Publication metadata

Author(s): Nouraei SAR, Hope KL, Kelly CG, McLean NR, Soames JV

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Plastic and Reconstructive Surgery:

Year of Conference: 2005

Pages: 1206-1213

ISSN: 0032-1052

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1097/01.prs.0000181654.68120.0f

DOI: 10.1097/01.prs.0000181654.68120.0f

Library holdings: Search Newcastle University Library for this item

ISBN: 15294242


Actions

Find at Newcastle University icon    Link to this publication


Share