Lookup NU author(s): Dr Alexandra Reis,
Dr Mark Levasseur,
Professor Keith Jones
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Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APC(cdh1) is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APC(cdh1) is active in mouse oocytes and is necessary to maintain prophase arrest.
Author(s): Reis A, Chang HY, Levasseur M, Jones KT
Publication type: Article
Publication status: Published
Journal: Nature Cell Biology
ISSN (print): 1465-7392
ISSN (electronic): 1476-4679
Publisher: Nature Publishing Group
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