Lookup NU author(s): Dr Jean-Philippe Marechal,
Dr Claire Hellio,
Professor Tony Clare
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The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quitione, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3 '-(P-chlorophenyl)avarone (3), 3 ',4 '-ethylenedithioavarone (4), 4 '-isopropylthioavarone (5), 4 '-tertbutylthioavarone (6), 4 '-propylthioavarone (7), 4 '-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 mu g/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica).
Author(s): Tsoukatou M, Marechal JP, Hellio C, Novakovic I, Tufegdzie S, Sladic D, Gasic MJ, Clare AS, Vagias C, Roussis V
Publication type: Article
Publication status: Published
ISSN (print): 1420-3049
ISSN (electronic): 1431-5165
Publisher: Molecular Diversity Preservation International
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