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Lookup NU author(s): Professor Johannes Attems
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PURPOSE: The aim of this retrospective study was to comparatively investigate the expression of the three drug-resistance genes P-glycoprotein (P-gp), multidrug-resistance protein 1 (MRP1), and lung resistance protein (LRP), in non-small cell lung cancer (NSCLC) tissues, and to assess possible associations with clinicopathologic features. METHODS: Tumor specimens from 126 patients were analyzed by immunohistochemistry and, in selected cases, by reverse transcriptase polymerase chain reaction (RT-PCR), and data were statistically analyzed by SPSS. RESULTS: The mean expression levels of tumor tissues in the case of P-gp and LRP did not exceed the one of normal epithelia, while MRP1 was significantly enhanced in NSCLC. A weak association was observed between higher grading and P-glycoprotein expression (p
Author(s): Berger W, Setinek U, Hollaus P, Zidek T, Steiner E, Elbling L, Cantonati H, Attems J, Gsur A, Micksche M
Publication type: Article
Publication status: Published
Journal: Journal of Cancer Research and Clinical Oncology
Year: 2005
Volume: 131
Issue: 6
Pages: 355-363
ISSN (print): 0171-5216
ISSN (electronic): 1432-1335
Publisher: Springer
URL: http://dx.doi.org/10.1007/s00432-004-0653-9
DOI: 10.1007/s00432-004-0653-9
Notes: Berger, Walter Setinek, Ulrike Hollaus, Peter Zidek, Thomas Steiner, Elisabeth Elbling, L Cantonati, H Attems, Johannes Gsur, Andrea Micksche, Michael Comparative Study Research Support, Non-U.S. Gov't Germany Journal of cancer research and clinical oncology J Cancer Res Clin Oncol. 2005 Jun;131(6):355-63. Epub 2005 Jan 27.
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