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Toward a PCR-Independent Molecular Diagnosis of Veterinary and Medically Relevant Pathogenic Organisms

Lookup NU author(s): Dr Dino Masic, Dr Andrew Berrington, Dr Olivier Sparagano

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Abstract

Bloodstream infections caused by bacteria and fungi are a major problem worldwide. These bloodstream infections can affect both people and livestock, placing a significant burden upon developed and developing economies. In this paper we describe a multiplexed testing format, which can identify a range of bacteria and fungi within a single blood sample. Key to this technique is the specificity and sensitivity of the nucleotide probes that capture the sample. The sensitivity and specificity of the probes may allow detection of disease-causing microorganisms without the need for polymerase chain reaction amplification if the dynamics of probe binding can be observed in real time.


Publication metadata

Author(s): Partington MW, Masic D, Nicholson A, Perry J, Berrington A, West J, Sparagano OAE

Editor(s): Sparagano, O; Maillard, JC; Figueroa, JV

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Animal Biodiversity and Emerging Diseases: Prediction and Prevention

Year of Conference: 2008

Pages: 391-393

ISSN: 0077-8923 (print) 1749-6632 (online)

Publisher: Wiley-Blackwell Publishing, Inc.

URL: http://dx.doi.org/10.1196/annals.1428.010

DOI: 10.1196/annals.1428.010

Library holdings: Search Newcastle University Library for this item

Series Title: Annals of the New York Academy of Sciences

ISBN: 9781573317146


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