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Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria

Lookup NU author(s): Dr Latika Sibal, Dr Ali Aldibbiat, Dr Sharad Agarwal, Crispian Oates, Dr Salman Razvi, Dr Jolanta Weaver, Professor James Shaw, Professor Philip Home

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Abstract

Type 1 diabetes is associated with premature arterial disease. Bone-marrow derived, circulating endothelial progenitor cells (EPCs) are believed to contribute to endothelial repair. The hypothesis tested was that circulating EPCs are reduced in young people with type 1 diabetes without vascular injury and that this is associated with impaired endothelial function and increased carotid intima-media thickness (CIMT). We compared 74 people with type 1 diabetes with 80 healthy controls. CD34, CD133, vascular endothelial (VE) growth factor receptor-2 (VEGFR-2) and VE-cadherin antibodies were used to quantify EPCs and progenitor cell subtypes using flow-cytometry. Ultrasound assessment of endothelial function by brachial artery flow-mediated dilatation (FMD) and CIMT was made. Circulating endothelial markers, inflammatory markers and plasma plasminogen activator inhibitor-1 (PAI-1) levels were measured. CD34+VE-cadherin+, CD133+VE-cadherin+ and CD133+VEGFR-2+ EPC counts were significantly lower in people with diabetes (46-69%; p = 0.004-0.043). In people with type 1 diabetes, FMD was reduced by 45% (p


Publication metadata

Author(s): Sibal L, Aldibbiat A, Agarwal SC, Mitchell G, Oates C, Razvi S, Weaver JU, Shaw JA, Home PD

Publication type: Article

Publication status: Published

Journal: Diabetologia

Year: 2009

Volume: 52

Issue: 8

Pages: 1464-1473

ISSN (print): 0012-186X

ISSN (electronic): 1432-0428

Publisher: Springer

URL: http://dx.doi.org/10.1007/s00125-009-1401-0

DOI: 10.1007/s00125-009-1401-0


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