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Pyrophosphate Transport and Stones

Lookup NU author(s): Professor John Sayer, Dr Georgina Carr, Dr Shabbir Moochhala, Professor Nicholas Simmons

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Abstract

Since the 1960's, inorganic pyrophosphate (PPi) has been known to inhibit apatite precipitation. Recent findings suggest that PPi plays a central role in the control of normal bone mineralization. Knockout mice have established the functional importance of PPi transmembrane transport, via the pyrophosphate transporter ANKH. The molecular nature and transport function of ANKH are reviewed. PPi is present in urine and ANKH is expressed in the cortical collecting duct where PPi transport to both the tubular lumen and renal interstitium may occur. Arginine vasopressin stimulation of cortical collecting duct cells grown on semipermeable supports appears to upregulate apical ANKH expression, which we postulate may be a mechanism of stone inhibition during urinary concentration and supersaturation of calcium salts. Hypopyrophosphaturia may be a forgotten metabolic risk factor for stone formation and polymorphisms of the ANKH gene may underlie this defect. The physiological importance and clinical significance of PPi generation and transport in preventing idiopathic renal stone disease and nephrocalcinosis now needs to be established.


Publication metadata

Author(s): Sayer JA, Carr G, Moochhala SH, Simmons NL

Editor(s): Evan, AP; Lingeman, JE; McAteer, JA; Williams, JC

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Renal Stone Disease: No. 2: 2nd International Urolithiasis Research Symposium

Year of Conference: 2008

Pages: 71-80

Publisher: American Institute of Physics

Library holdings: Search Newcastle University Library for this item

Series Title: AIP Conference Proceedings

ISBN: 9780735405776


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