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Health-related quality of life in survivors of BMT for paediatric malignancy: a systematic review of the literature

Lookup NU author(s): Professor Roderick Skinner


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We review evidence concerning health-related quality of life (HRQL) following paediatric haemopoietic stem cell transplant. The aims are to determine (1) HRQL compared with population norms; (2) changes in HRQL over time and (3) relations between pre-transplant variables (disease, individual and family resources) and survivor HRQL. Five databases were searched for articles published between January 1990 and February 2008. A total of 15 studies including 12 separate cohorts were identified. (1) HRQL was comparable with or better than population norms 6 months to 8 years post transplant. (2) HRQL was already compromised pre-transplant, further impaired immediately following conditioning, but improved 4 - 12 months post transplant. (3) Pre-transplant predictors of HRQL include family functioning and individual resources (for example, social skills). Identification of pre-transplant variables associated with long-term HRQL is invaluable to inform early psychological intervention and facilitate positive adjustment.

Publication metadata

Author(s): Clarke SA, Eiser C, Skinner R

Publication type: Review

Publication status: Published

Journal: Bone Marrow Transplantation

Year: 2008

Volume: 42

Issue: 2

Pages: 73-82

ISSN (print): 0268-3369

ISSN (electronic): 1476-5365



DOI: 10.1038/bmt.2008.156


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