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The second-meal phenomenon is associated with enhanced muscle glycogen storage in humans

Lookup NU author(s): Dr Ana Jovanovic, Dr Balasubramanian Ravikumar, Professor Roy Taylor

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Abstract

The rise in blood glucose after lunch is less if breakfast has been eaten. The metabolic basis of this second-meal phenomenon remains uncertain. We hypothesized that storage of ingested glucose as glycogen could be responsible during the post-meal suppression of plasma NEFAs (non-esterified fatty acids; 'free' fatty acids). In the present study we determined the metabolic basis of the second-meal phenomenon. Healthy subjects were studied on two separate days, with breakfast and without breakfast in a random order. We studied metabolic changes after a standardized test lunch labelled with 3 g of C-13-labelled (99%) glucose. Changes in post-prandial muscle glycogen storage were measured using C-13 magnetic resonance spectroscopy. The rise in plasma glucose after lunch was significantly less if breakfast had been taken (0.9 +/- 0.3 compared with 3.2 +/- 0.3 mmol/l, with and without breakfast respectively; P


Publication metadata

Author(s): Jovanovic A, Leverton E, Solanky B, Ravikumar B, Snaar JEM, Morris PG, Taylor R

Publication type: Article

Publication status: Published

Journal: Clinical Science

Year: 2009

Volume: 117

Issue: 3

Pages: 119-127

Date deposited: 15/12/2009

ISSN (print): 0143-5221

ISSN (electronic): 1470-8736

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/CS20080542

DOI: 10.1042/CS20080542


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