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Lookup NU author(s): Dr Kevin WaldronORCiD, Dr Julian Rutherford, Professor Dianne Ford, Professor Nigel Robinson
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Almost half of all enzymes must associate with a particular metal to function. An ambition is to understand why each metal-protein partnership arose and how it is maintained. Metal availability provides part of the explanation, and has changed over geological time and varies between habitats but is held within vital limits in cells. Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.
Author(s): Waldron KJ, Rutherford JC, Ford D, Robinson NJ
Publication type: Review
Publication status: Published
Journal: Nature
Year: 2009
Volume: 460
Issue: 7257
Pages: 823-830
ISSN (print): 0028-0836
ISSN (electronic): 1476-4687
URL: http://dx.doi.org/10.1038/nature08300
DOI: 10.1038/nature08300
