Lookup NU author(s): Dr Andrea Tasker,
Dr Clive Ballard,
Dr Edward Okello,
Emeritus Professor Robert Perry,
Emeritus Professor Elaine Perry
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue. We studied 164 autopsy cases, 144 with dementia and 20 controls, including 13 K homozygotes and 48 K heterozygotes, from three centres: Newcastle, Oxford and London. Mean BuChE activity in temporal cortex was 37% higher in K homozygotes than in wild-type homozygotes. Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p = 0.009). (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Author(s): Tasker A, Ballard CG, Joachim C, Warden DR, Okello EJ, Perry RH, Khan N, Smith AD, Lehmann DJ, Perry EK
Publication type: Article
Publication status: Published
Journal: Neuroscience Letters
ISSN (print): 0304-3940
ISSN (electronic): 1872-7972
Altmetrics provided by Altmetric