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Resistance of Polysaccharide Coatings to Proteins, Hematopoietic Cells, and Marine Organisms

Lookup NU author(s): Sheelagh Conlan, Professor Tony Clare

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Abstract

The interaction of covalently coupled hyaluronic acid, alginic acid, and pectic acid with proteins, cells (hematopoietic KG I a and Jurkat cells), and marine organisms (algal zoospores and barnacle cypris larvae) is compared. In contrast to cells and proteins for which such polysaccharide coatings are known for their antiadhesive properties, marine algal spores and barnacle cyprids were able to colonize the surfaces. Of the three polysaccharides, hyaluronic acid showed the lowest settlement of both Ulva zoopores and barnacles. Photoelectron spectroscopy reveals that the polysaccharide coatings tend to bind bivalent ions, such as calcium, from salt water. Such pretreatment with a high salinity medium significantly changes the protein and hematopoietic cell resistance of the surfaces. Complexation of bivalent ions is therefore considered as one reason for the decreased resistance of polysaccharide coatings when applied in the marine environment.


Publication metadata

Author(s): Cao XY, Pettit ME, Conlan SL, Wagner W, Ho AD, Clare AS, Callow JA, Callow ME, Grunze M, Rosenhahn A

Publication type: Article

Publication status: Published

Journal: Biomacromolecules

Year: 2009

Volume: 10

Issue: 4

Pages: 907-915

ISSN (print): 1525-7797

ISSN (electronic): 1526-4602

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/bm8014208

DOI: 10.1021/bm8014208


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