Lookup NU author(s): Sheelagh Conlan,
Professor Tony Clare
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The interaction of covalently coupled hyaluronic acid, alginic acid, and pectic acid with proteins, cells (hematopoietic KG I a and Jurkat cells), and marine organisms (algal zoospores and barnacle cypris larvae) is compared. In contrast to cells and proteins for which such polysaccharide coatings are known for their antiadhesive properties, marine algal spores and barnacle cyprids were able to colonize the surfaces. Of the three polysaccharides, hyaluronic acid showed the lowest settlement of both Ulva zoopores and barnacles. Photoelectron spectroscopy reveals that the polysaccharide coatings tend to bind bivalent ions, such as calcium, from salt water. Such pretreatment with a high salinity medium significantly changes the protein and hematopoietic cell resistance of the surfaces. Complexation of bivalent ions is therefore considered as one reason for the decreased resistance of polysaccharide coatings when applied in the marine environment.
Author(s): Cao XY, Pettit ME, Conlan SL, Wagner W, Ho AD, Clare AS, Callow JA, Callow ME, Grunze M, Rosenhahn A
Publication type: Article
Publication status: Published
ISSN (print): 1525-7797
ISSN (electronic): 1526-4602
Publisher: American Chemical Society
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