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Transcriptional regulation of hepatic stellate cells

Lookup NU author(s): Professor Jelena Mann, Professor Derek Mann

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Abstract

Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogenic activities. This remarkable phenotypic transformation is underpinned by changes in the expression of a vast number of genes. In this review we survey current knowledge of the transcription factors that either control HSC activation or which regulate specific fibrogenic functions of the activated HSC such as collagen expression, proliferation and resistance to apoptosis. (C) 2009 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Mann J, Mann DA

Publication type: Article

Publication status: Published

Journal: Advanced Drug Delivery Reviews

Year: 2009

Volume: 61

Issue: 7-8

Pages: 497-512

ISSN (print): 0169-409X

ISSN (electronic): 1872-8294

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.addr.2009.03.011

DOI: 10.1016/j.addr.2009.03.011

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