Lookup NU author(s): Professor Jelena Mann,
Professor Derek Mann
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Hepatic stellate cell (HSC) activation is a process of cellular transdifferentiation in which, upon liver injury, the quiescent vitamin A storing perisinusoidal HSC is converted into a wound-healing myofibroblast and acquires potent pro-inflammatory and pro-fibrogenic activities. This remarkable phenotypic transformation is underpinned by changes in the expression of a vast number of genes. In this review we survey current knowledge of the transcription factors that either control HSC activation or which regulate specific fibrogenic functions of the activated HSC such as collagen expression, proliferation and resistance to apoptosis. (C) 2009 Elsevier B.V. All rights reserved.
Author(s): Mann J, Mann DA
Publication type: Article
Publication status: Published
Journal: Advanced Drug Delivery Reviews
ISSN (print): 0169-409X
ISSN (electronic): 1872-8294
Publisher: Elsevier BV
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