Lookup NU author(s): Dr Jian Shi
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The conditional likelihood approach is a sensible choice fora hierarchical logistic regression model or other generalized regression models with binary data. However, its heavy computational burden limits its use, especially for the related mixed-effects model. A modified profile likelihood is used as an accurate approximation to conditional likelihood, and then the use of two methods for inferences for the hierarchical generalized regression models with mixed effects is proposed. One is based on a hierarchical likelihood and Laplace approximation method, and the other is based on a Markov chain Monte Carlo EM algorithm. The methods are applied to a meta-analysis model for trend estimation and the model for multi-arm trials. A simulation study is conducted to illustrate the performance of the proposed methods. (C) 2009 Elsevier B.V. All rights reserved.
Author(s): Lee W, Shi JQ, Lee Y
Publication type: Article
Publication status: Published
Journal: Computational Statistics & Data Analysis
Print publication date: 01/01/2010
ISSN (print): 0167-9473
ISSN (electronic): 1872-7352
Publisher: Elsevier BV
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