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Lookup NU author(s): Professor Angharad MR Gatehouse
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Analysis of the pea aphid (Acyrthosiphon pisum) genome using signatures specific to the Major Facilitator Superfamily (Pfam Clan CL0015) and the Sugar_tr family (Pfam Family PF00083) has identified 54 genes encoding potential sugar transporters, of which 38 have corresponding ESTs. Twenty-nine genes contain the InterPro IPR003663 hexose transporter signature. The protein encoded by Ap_ST3, the most abundantly expressed sugar transporter gene, was functionally characterized by expression as a recombinant protein. Ap_ST3 acts as a low-affinity uniporter for fructose and glucose that does not depend on Na+ or H+ for activity. Ap_ST3 was expressed at elevated levels in distal gut tissue, consistent with a role in gut sugar transport. The A. pisum genome shows evidence of duplications of sugar transporter genes.
Author(s): Price DRG, Tibbles K, Shigenobu S, Smertenko A, Russell CW, Douglas AE, Fitches E, Gatehouse AMR, Gatehouse JA
Publication type: Article
Publication status: Published
Journal: Insect Molecular Biology
Print publication date: 01/03/2010
ISSN (print): 0962-1075
ISSN (electronic): 1365-2583
Publisher: Wiley-Blackwell Publishing Ltd.
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