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Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome

Lookup NU author(s): Professor David Jones, Dr Kieren Hollingsworth, Professor Roy Taylor, Professor Andrew Blamire, Professor Julia Newton

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Abstract

Jones DEJ, Hollingsworth KG, Taylor R, Blamire AM, Newton JL (From the Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, and Institute for Ageing and Health, Newcastle University, UK). Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome. J Intern Med 2010; 267: 394-401. Objectives. To examine muscle acid handling following exercise in chronic fatigue syndrome (CFS/ME) and the relationship with autonomic dysfunction. Design. Observational study. Setting. Regional fatigue service. Subjects & interventions. Chronic fatigue syndrome (n = 16) and age and sex matched normal controls (n = 8) underwent phosphorus magnetic resonance spectroscopy (MRS) to evaluate pH handling during exercise. Subjects performed plantar flexion at fixed 35% load maximum voluntary contraction. Heart rate variability was performed during 10 min supine rest using digital photophlethysmography as a measure of autonomic function. Results. Compared to normal controls, the CFS/ME group had significant suppression of proton efflux both immediately postexercise (CFS: 1.1 +/- 0.5 mmol L-1 min-1 vs. normal: 3.6 +/- 1.5 mmol L-1 min-1, P < 0.001) and maximally (CFS: 2.7 +/- 3.4 mmol L-1 min-1 vs. control: 3.8 +/- 1.6 mmol L-1 min-1, P < 0.05). Furthermore, the time taken to reach maximum proton efflux was significantly prolonged in patients (CFS: 25.6 +/- 36.1 s vs. normal: 3.8 +/- 5.2 s, P < 0.05). In controls the rate of maximum proton efflux showed a strong inverse correlation with nadir muscle pH following exercise (r2 = 0.6; P < 0.01). In CFS patients, in contrast, this significant normal relationship was lost (r2 = 0.003; P = ns). In normal individuals, the maximum proton efflux following exercise were closely correlated with total heart rate variability (r2 = 0.7; P = 0.007) this relationship was lost in CFS/ME patients (r2 < 0.001; P = ns). Conclusion. Patients with CFS/ME have abnormalities in recovery of intramuscular pH following standardised exercise degree of which is related to autonomic dysfunction. This study identifies a novel biological abnormality in patients with CFS/ME which is potentially open to modification.


Publication metadata

Author(s): Jones DEJ, Hollingsworth KG, Taylor R, Blamire AM, Newton JL

Publication type: Article

Publication status: Published

Journal: Journal of Internal Medicine

Year: 2010

Volume: 267

Issue: 4

Pages: 394-401

Print publication date: 01/04/2010

ISSN (print): 0954-6820

ISSN (electronic): 1365-2796

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1365-2796.2009.02160.x

DOI: 10.1111/j.1365-2796.2009.02160.x


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