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Genome-wide association studies in pharmacogenomics

Lookup NU author(s): Professor Ann Daly

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Abstract

Genome-wide association (GWA) studies for pharmacogenomics-related traits are increasingly being performed to identify loci that affect either drug response or susceptibility to adverse drug reactions. Until now, only the largest effects have been detected, partly because of the challenges of obtaining large numbers of cases for pharmacogenomic studies. Since 2007, a range of pharmacogenomics GWA studies have been published that have identified several interesting and novel associations between drug responses or reactions and clinically relevant loci, showing the value of this approach.


Publication metadata

Author(s): Daly AK

Publication type: Review

Publication status: Published

Journal: Nature Reviews: Genetics

Year: 2010

Volume: 11

Issue: 4

Pages: 241-246

Print publication date: 01/04/2010

ISSN (print): 1471-0056

ISSN (electronic): 1471-0064

URL: http://dx.doi.org/10.1038/nrg2751

DOI: 10.1038/nrg2751


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