Lookup NU author(s): Stuart Robinson,
Professor Derek Mann
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NF-kappa B (nuclear factor kappa B) is a heterodimeric transcription factor that is constitutively expressed in all cell types and has a central role as a transcriptional regulator in response to cellular stress. In the present review, we discuss the role of NF-kappa B signalling in the maintenance of liver homoeostasis as well as in the pathogenesis of a wide variety of conditions affecting the liver, including viral hepatitis, steatohepatitis, cirrhosis and hepatocellular carcinoma. Much of the current knowledge of NF-kappa B signalling in the liver relates to the canonical pathway, the IKK [I kappa B (inhibitor of kappa B) kinase] complex and the RelA subunit. We explore the weaknesses of the experimental approaches to date and suggest that further work is needed to investigate in detail the discreet functions of each of the Rel subunits in liver physiology and disease.
Author(s): Robinson SM, Mann DA
Publication type: Review
Publication status: Published
Journal: Clinical Science
Print publication date: 01/06/2010
ISSN (print): 0143-5221
ISSN (electronic): 1470-8736
Publisher: PORTLAND PRESS LTD