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Role of nuclear factor kappa B in liver health and disease

Lookup NU author(s): Stuart Robinson, Professor Derek Mann

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Abstract

NF-kappa B (nuclear factor kappa B) is a heterodimeric transcription factor that is constitutively expressed in all cell types and has a central role as a transcriptional regulator in response to cellular stress. In the present review, we discuss the role of NF-kappa B signalling in the maintenance of liver homoeostasis as well as in the pathogenesis of a wide variety of conditions affecting the liver, including viral hepatitis, steatohepatitis, cirrhosis and hepatocellular carcinoma. Much of the current knowledge of NF-kappa B signalling in the liver relates to the canonical pathway, the IKK [I kappa B (inhibitor of kappa B) kinase] complex and the RelA subunit. We explore the weaknesses of the experimental approaches to date and suggest that further work is needed to investigate in detail the discreet functions of each of the Rel subunits in liver physiology and disease.


Publication metadata

Author(s): Robinson SM, Mann DA

Publication type: Review

Publication status: Published

Journal: Clinical Science

Year: 2010

Volume: 118

Issue: 11-12

Pages: 691-705

Print publication date: 01/06/2010

ISSN (print): 0143-5221

ISSN (electronic): 1470-8736

Publisher: PORTLAND PRESS LTD

URL: http://dx.doi.org/10.1042/CS20090549

DOI: 10.1042/CS20090549


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