Lookup NU author(s): Dr Henrik Strahl von Schulten,
Dr Leendert Hamoen
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Many cell division-related proteins are located at specific positions in the bacterial cell, and this organized distribution of proteins requires energy. Here, we report that the proton motive force, or morespecifically the (trans)membrane potential, is directly involved in protein localization. It emerged that the membrane potential modulates the distribution of several conserved cell division proteins such as MinD, FtsA, and the bacterial cytoskeletal protein MreB. We show for MinD that this is based on the membrane potential stimulated binding of its C-terminal amphipathic helix. This function of the membrane potential has implications for how these morphogenetic proteins work and provide an explanation for the effects observed with certain antimicrobial compounds.
Author(s): Strahl H, Hamoen LW
Publication type: Article
Publication status: Published
Journal: Proceedings of the National Academy of Sciences
Print publication date: 21/06/2010
ISSN (print): 0027-8424
ISSN (electronic): 1091-6490
Publisher: National Academy of Sciences
Altmetrics provided by Altmetric