Toggle Main Menu Toggle Search

Open Access padlockePrints

Profound invariant natural killer T-cell deficiency in inflammatory arthritis

Lookup NU author(s): Dr Susan Tudhope, Dr Alexei von Delwig, Dr Jane Falconer, Dr Arthur Pratt, Professor John Isaacs, Professor Fai Ng

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Objectives Data from rodent models indicate that invariant natural killer T (iNKT) cells are key regulators of many immune responses including autoimmune arthritis, but their role in human diseases is unclear. The aims of this study are to determine whether iNKT cell frequency and function are altered in patients with rheumatoid arthritis (RA), and the clinical significance of such iNKT cell abnormalities. Methods Peripheral blood iNKT cell frequency and proliferative response to an iNKT cell-specific agonist, a-galactosylceramide were measured in 46 RA patients (including 23 untreated, newly diagnosed patients), 22 healthy controls and 27 patients presenting with recent-onset joint pain. The relationship between iNKT cell frequency and clinical characteristics and the effects of immunosuppressive treatment was examined. Results Compared with healthy controls, RA patients had a decreased frequency of peripheral blood iNKT cells (median 0.001% vs 0.021%, p < 0.001) and the proliferative response of this subset to a-galactosylceramide was also diminished in the patient group (median fold-expansion 31 vs 121, p = 0.037). These abnormalities preceded the initiation of disease-modifying or immunosuppressive therapy, whose effect was to increase the circulating iNKT cell frequency (p = 0.037). Furthermore, iNKT cell frequency correlated inversely with the systemic inflammatory marker, C-reactive protein (p = 0.008). Finally, in patients presenting with recent-onset joint symptoms, normal peripheral blood iNKT cell frequency predicted a non-inflammatory cause of joint pain. Conclusion iNKT cell deficiency is present in patients with RA and other inflammatory arthropathy. Normal iNKT cell frequency predicts non-inflammatory causes of joint pain.


Publication metadata

Author(s): Tudhope SJ, von Delwig A, Falconer J, Pratt A, Woolridge T, Wilson G, Isaacs JD, Ng WF

Publication type: Article

Publication status: Published

Journal: Annals of the Rheumatic Diseases

Year: 2010

Volume: 69

Issue: 10

Pages: 1873-1879

Print publication date: 05/05/2010

ISSN (print): 0003-4967

ISSN (electronic): 1468-2060

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/ard.2009.125849

DOI: 10.1136/ard.2009.125849


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share