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Soluble E-cadherin: An early marker of severity in acute pancreatitis

Lookup NU author(s): Richard Charnley, Dr Avinash Sewpaul, Jeremy French, Dr Tien Kheng Khoo, Professor John Kirby

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Abstract

Background/Aims. At present, there is no simple test for predicting severity in acute pancreatitis. We investigated the use of an assay of soluble E-cadherin (sE-cadherin). Methods. Concentrations of sE-cadherin, from 19 patients with mild acute pancreatitis, 7 patients with severe acute pancreatitis, 11 patients with other acute gastrointestinal pathologies, and 12 healthy subjects were measured using a commercially available sandwich ELISA kit based on two monoclonal antibodies specific to the extracellular fragment of human E-cadherin. Measurements were made at 12 hours or less from onset of pain and also at 24 and 48 hours after onset of pain. Results. Mean (standard deviation) concentration of sE-cadherin in patients with severe acute pancreatitis at < 12 hours was 17780 ng/mL (7853), significantly higher than that of healthy volunteers 5180 ng/mL (1350), P =.0039, patients with other gastrointestinal pathologies 7358 ng/mL (6655), P =.0073, and also significantly higher than that of patients with mild pancreatitis, 7332 ng/mL (2843), P =.0019. Discussion. Serum sE-cadherin could be an early (within 12 hours) objective marker of severity in acute pancreatitis. This molecule warrants further investigation in the form of a large multicentre trial.


Publication metadata

Author(s): Charnley R, Sewpaul A, French J, Khoo T, Kernohan M, Kirby J

Publication type: Article

Publication status: Published

Journal: HPB Surgery

Year: 2009

Pages: article ID: 397375

ISSN (print): 0894-8569

ISSN (electronic): 1607-8462

Publisher: Hindawi Publishing Corporation

URL: http://dx.doi.org/10.1155/2009/397375

DOI: 10.1155/2009/397375


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