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Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systemswide level

Lookup NU author(s): Yilei Liu, Professor David Elliott

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Abstract

Nuclear RNA processing is a critical stage in eukaryotic gene expression, and is controlled in part by the expression and concentration of nuclear RNA-binding proteins. Different nuclear RNA-binding proteins are differentially expressed in different cells, helping the spliceosome to decode pre-mRNAs into alternatively spliced mRNAs. Recent post-genomic technology has exposed the complexity of nuclear RNA processing, and is starting to reveal the mechanisms and rules through which networks of RNA-binding proteins can regulate multiple parallel pathways. Identification of multiple parallel processing pathways regulated by nuclear RNA-binding proteins is leading to a systems-wide understanding of the rules and consequences of alternative nuclear RNA processing. © The Authors Journal compilation.


Publication metadata

Author(s): Liu Y, Elliott D

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2010

Volume: 38

Issue: 1

Pages: 237-241

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST0380237

DOI: 10.1042/BST0380237


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