Toggle Main Menu Toggle Search

Open Access padlockePrints

Defective Mitochondrial mRNA Maturation Is Associated with Spastic Ataxia

Lookup NU author(s): Professor Zofia Chrzanowska-Lightowlers, Professor Robert Lightowlers

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

In human mitochondria, polyadenylation of mRNA undertaken by the nuclear encoded mitochondrial poly(A) RNA polymerase, is essential for maintaining mitochondrial gene expression Our molecular investigation of an autosomal recessive spastic ataxia with optic atrophy, present among the Old Order Amish, identified a mutation of MTPAP associated with the disease phenotype When subjected to poly(A) tail length assays mitochondrial mRNAs from affected individuals were shown to have severely truncated poly(A) tails Although defective mitochondrial DNA maintenance underlies a well described group of clinical disorders, our findings reveal a defect of mitochondrial mRNA maturation associated with human disease and imply that this disease mechanism should be considered in other complex neurodegenerative disorders


Publication metadata

Author(s): Crosby AH, Patel H, Chioza BA, Proukakis C, Gurtz K, Patton MA, Sharifi R, Harlalka G, Simpson MA, Dick K, Reed JA, Al-Memar A, Chrzanowska-Lightowlers ZMA, Cross HE, Lightowlers RN

Publication type: Article

Publication status: Published

Journal: American Journal of Human Genetics

Year: 2010

Volume: 87

Issue: 5

Pages: 655-660

Print publication date: 21/10/2010

ISSN (print): 0002-9297

ISSN (electronic): 1537-6605

Publisher: Cell Press

URL: http://dx.doi.org/10.1016/j.ajhg.2010.09.013

DOI: 10.1016/j.ajhg.2010.09.013


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share