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The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research

Lookup NU author(s): Professor John Edward Hesketh, Professor Georg Lietz, Professor John Mathers, Dr Catherine Meplan

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Abstract

Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, for maintaining good health. With advances in systems biology and genomics technologies, it is becoming feasible to assess the activity of single and multiple micronutrients in their complete biological context. Existing research collects fragments of information, which are not stored systematically and are thus not optimally disseminated. The Micronutrient Genomics Project (MGP) was established as a community-driven project to facilitate the development of systematic capture, storage, management, analyses, and dissemination of data and knowledge generated by biological studies focused on micronutrient-genome interactions. Specifically, the MGP creates a public portal and open-source bioinformatics toolbox for all "omics" information and evaluation of micronutrient and health studies. The core of the project focuses on access to, and visualization of, genetic/genomic, transcriptomic, proteomic and metabolomic information related to micronutrients. For each micronutrient, an expert group is or will be established combining the various relevant areas (including genetics, nutrition, biochemistry, and epidemiology). Each expert group will (1) collect all available knowledge, (2) collaborate with bioinformatics teams towards constructing the pathways and biological networks, and (3) publish their findings on a regular basis. The project is coordinated in a transparent manner, regular meetings are organized and dissemination is arranged through tools, a toolbox web portal, a communications website and dedicated publications.


Publication metadata

Author(s): van Ommen B, El-Sohemy A, Hesketh J, Kaput J, Fenech M, Evelo CT, McArdle HJ, Bouwman J, Lietz G, Mathers JC, Fairweather-Tait S, van Kranen H, Elliott R, Wopereis S, Ferguson LR, Meplan C, Perozzi G, Allen L, Rivero D, Micronutrient Genomics Project Wor

Publication type: Review

Publication status: Published

Journal: Genes & Nutrition

Year: 2010

Volume: 5

Issue: 4

Pages: 285-296

Print publication date: 04/11/2010

ISSN (print): 1555-8932

ISSN (electronic): 1865-3499

Publisher: SPRINGER

URL: http://dx.doi.org/10.1007/s12263-010-0192-81007

DOI: 10.1007/s12263-010-0192-8


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