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Efficacy of a single ultrasound-guided injection for the treatment of hip osteoarthritis

Lookup NU author(s): Dr Ismael Atchia, Dr David Kane, Michael Reed, Professor John Isaacs, Dr Fraser Birrell

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Abstract

Background Intra-articular injection is effective for osteoarthritis, but the best single injection strategy is not known, nor are there established predictors of response. The objectives of this study were to assess and predict response to a single ultrasound-guided injection in moderate to severe hip osteoarthritis. Methods 77 hip osteoarthritis patients entered a prospective, randomised controlled trial, randomised to one of four groups: standard care (no injection); normal saline; non-animal stabilised hyaluronic acid (durolane) or methylprednisolone acetate (depomedrone). Main Outcome Measures Numerical rating scale (NRS 0-10) 'worst pain', Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain/function. Potential predictors of response (including radiographic severity, ultrasound synovitis and baseline symptom severity) were examined using univariate logistic regression analysis and Fisher's exact test. Results NRS pain, WOMAC pain and function improved significantly for the steroid arm alone. Effect sizes at week 1 were striking: NRS pain 1.5, WOMAC pain 1.9 and WOMAC function 1.3. Outcome Measures in Rheumatoid Arthritis Clinical Trials-Osteoarthritis Research Society responder criteria identified 22 responders (intention-to-treat): steroid 14 (74%; number needed to treat, two); saline, four (21%); durolane, two (11%); and no injection, two (10%; chi(2) test between groups, p < 0.001). Corticosteroid arm response was maintained over 8 weeks (summary measures analysis of variance, p < 0.002 for NRS pain). Synovitis was a significant predictor of response at weeks 4 and 8 (p < 0.05, Fisher's exact test; week 4 OR 16.7, 95% CI 1.4 to 204). Conclusions Ultrasound-guided corticosteroid injections are highly efficacious; furthermore synovitis on ultrasound is a biomarker of response to injection.


Publication metadata

Author(s): Atchia I, Kane D, Reed MR, Isaacs JD, Birrell F

Publication type: Article

Publication status: Published

Journal: Annals of the Rheumatic Diseases

Year: 2011

Volume: 70

Issue: 1

Pages: 110-116

Print publication date: 10/11/2010

ISSN (print): 0003-4967

ISSN (electronic): 1468-2060

Publisher: BMJ Publishing Group

URL: http://dx.doi.org/10.1136/ard.2009.127183

DOI: 10.1136/ard.2009.127183


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