Lookup NU author(s): Professor Ann Daly
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The present article summarizes the discussions of the 3rd European Science Foundation University of Barcelona (ESF-UB) Conference in Biomedicine on Pharmacogenetics and Pharmacogenomics, which was held in June 2010 in Spain. It was focused on practical applications in routine medical practice. We provide practical recommendations for ten different clinical situations, that have either been approved or not approved by regulatory agencies. We propose some comments that might accompany the results of these tests, indicating the best drug and doses to be prescribed. The discussed examples include KRAS, cetuximab, panitumumab, EGFR gefitinib, CYP2D6-tamoxifen, TPMT azathioprine-6-mercaptopurine, VKORC1/CYP2C9 warfarin, CYP2C19-clopidogrel, HLA-B*5701-abacavir, HLA-B*5701-flucloxacillin, SLCO1B1-statins and CYP3A5-tacrolimus. We hope that these practical recommendations will help physicians, biologists, scientists and other healthcare professionals to prescribe, perform and interpret these genetic tests.
Author(s): Becquement L, Alfrieve A, Amstutz U, Brauch H, Jacqz-Algrain E, Laurent-Puig P, Molina MA, Niemi M, Schwab M, Somogyi AA, Thervet E, Maitland-van der Zee AH, van Kuilenburg ABP, van Schaik RHN, Verstuyft C, Wadelius M, Daly AK
Publication type: Article
Publication status: Published
Print publication date: 01/01/2011
ISSN (print): 1462-2416
ISSN (electronic): 1744-8042
Publisher: Future Medicine Ltd
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