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Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics

Lookup NU author(s): Professor Ann Daly

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Abstract

The present article summarizes the discussions of the 3rd European Science Foundation University of Barcelona (ESF-UB) Conference in Biomedicine on Pharmacogenetics and Pharmacogenomics, which was held in June 2010 in Spain. It was focused on practical applications in routine medical practice. We provide practical recommendations for ten different clinical situations, that have either been approved or not approved by regulatory agencies. We propose some comments that might accompany the results of these tests, indicating the best drug and doses to be prescribed. The discussed examples include KRAS, cetuximab, panitumumab, EGFR gefitinib, CYP2D6-tamoxifen, TPMT azathioprine-6-mercaptopurine, VKORC1/CYP2C9 warfarin, CYP2C19-clopidogrel, HLA-B*5701-abacavir, HLA-B*5701-flucloxacillin, SLCO1B1-statins and CYP3A5-tacrolimus. We hope that these practical recommendations will help physicians, biologists, scientists and other healthcare professionals to prescribe, perform and interpret these genetic tests.


Publication metadata

Author(s): Becquement L, Alfrieve A, Amstutz U, Brauch H, Jacqz-Algrain E, Laurent-Puig P, Molina MA, Niemi M, Schwab M, Somogyi AA, Thervet E, Maitland-van der Zee AH, van Kuilenburg ABP, van Schaik RHN, Verstuyft C, Wadelius M, Daly AK

Publication type: Article

Publication status: Published

Journal: Pharmacogenomics

Year: 2011

Volume: 12

Issue: 1

Pages: 113-124

Print publication date: 01/01/2011

ISSN (print): 1462-2416

ISSN (electronic): 1744-8042

Publisher: Future Medicine Ltd

URL: http://dx.doi.org/10.2217/PGS.10.147

DOI: 10.2217/PGS.10.147


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