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The Effect of Drug Treatment on Neurogenesis in Parkinson's Disease

Lookup NU author(s): Emeritus Professor Elaine Perry

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Abstract

There has been recent interest in the possibility that impaired neurogenesis may contribute to the decline in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease (PD). We have investigated the effects of commonly used treatments for PD on neural stem cell (NSC) activity in nondemented patients. Postmortem of brain tissue containing the sub-ventricular zone (SVZ) and ependymal layer cells was obtained from 32 nondemented patients with PD. NSC activity was assessed by immunohistochemical staining for RNA-binding protein Musashi1. Regression analyses were then used to identify which clinical factors independently influenced NSC activity. Disease duration was negatively associated with SVZ Musashi1 staining, whereas lifetime levodopa was positively associated in this region. Our findings suggest a positive impact of chronic L-dopa use on the number of NSC in the SVZ of PD patients, which may have relevance for future studies on neuroprotection in neurodegenerative diseases. (C) 2010 Movement Disorder Society

Publication metadata

Author(s): O'Sullivan SS, Johnson M, Williams DR, Revesz T, Holton JL, Lees AJ, Perry EK

Publication type: Article

Publication status: Published

Journal: Movement Disorders

Year: 2011

Volume: 26

Issue: 1

Pages: 45-50

Print publication date: 01/01/2011

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/23340

DOI: 10.1002/23340

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