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Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample

Lookup NU author(s): Professor Jeremy Parr, Professor Ann Le Couteur

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Abstract

The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. © 2010 Springer Science+Business Media, LLC.

Publication metadata

Author(s): Parr J, Le Couteur A, Baird G, Rutter M, Pickles A, Fombonne E, Bailey A

Publication type: Article

Publication status: Published

Journal: Journal of Autism and Developmental Disorders

Year: 2010

Volume: 41

Issue: 3

Pages: 332-340

Print publication date: 14/08/2010

ISSN (print): 0162-3257

ISSN (electronic): 1573-3432

Publisher: Springer New York LLC

URL: http://dx.doi.org/10.1007/s10803-010-1055-2

DOI: 10.1007/s10803-010-1055-2

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