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Effects of Cadmium Chloride and Sodium Selenite Alone or in Combination on the Liver of Male Sprague–Dawley Rats Assessed by Different Assays

Lookup NU author(s): Dr Farhat Jabeen, Dr Abdul Chaudhry

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Abstract

This study assessed the impact of either cadmium chloride (Cd) or sodium selenite (Se) alone or in combination on male Sprague-Dawley rats. For this purpose, body and liver weights, comet and TUNEL assays, histological analysis and levels of lipid peroxidation and antioxidants in liver were determined in four groups of male Sprague-Dawley rats. The rats were given subcutaneous doses of 1 mg/kg body weight (BW) of either normal saline (control = Ct) or Cd or Se or Cd plus Se (Cd + Se) on alternate days for 4 weeks. The Cd group showed increased DNA damage, apoptosis and hepatic levels of lipid peroxidation and altered histology. Conversely, the antioxidant levels in this group were decreased as compared with the control group. The Se group also showed DNA damage, apoptosis and altered histology and reduced catalase activity, but it was less severe than the Cd group. In the Cd + Se group, ameliorating effects of Se on Cd-induced changes were observed. While the Se was able to curtail the toxic effect of Cd, the Cd or Se alone were genotoxic and cytotoxic for rats receiving a high pharmacological but non-fatal dose of 1 mg/kg BW. © 2011 Springer Science+Business Media, LLC.


Publication metadata

Author(s): Jabeen F, Chaudhry A

Publication type: Article

Publication status: Published

Journal: Biological Trace Element Research

Year: 2011

Volume: 143

Issue: 2

Pages: 1077-1090

Print publication date: 07/01/2011

ISSN (print): 0163-4984

ISSN (electronic): 1559-0720

Publisher: Humana Press, Inc.

URL: http://dx.doi.org/10.1007/s12011-010-8946-0

DOI: 10.1007/s12011-010-8946-0


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